People have long used cannabis plants for medical and recreational purposes. Compounds called cannabinoids in plants are responsible for the effects on the brain, the two most common of which are tetrahydrocannabinol (THC) and cannabidiol (CBD).
THC and CBD are psychotropic drugs, but they have different effects on the brain. Unlike THC, CBD is fault-free. People use CBD for many reasons, including seizures, anxiety, and pain relief. Some studies have indicated that CBD can also be a sleep aid. In this article, we’ll look at whether it works and the risks associated with it.
Research and its results
Over the last decade, growing public interest in the benefits of marijuana, especially CBD, has led researchers to study its effects. Early studies suggest that high doses of CBD may help sleep. One study found that administration of 160 milligrams (mg) of CBD increased sleep time compared to placebo. The researchers also concluded that placebo, the 5 mg hypnotic nitrazepam, and 40, 80, and 160 mg of CBD helped participants sleep. The stress hormone cortisol levels are usually the highest in the morning, but people with insomnia can have higher cortisol levels at night. High nocturnal cortisol levels are associated with an increased number of nocturnal awakenings, regardless of insomnia. In a study of the effects of CBD, researchers found that cortisol levels were significantly reduced when participants ingested 300 or 600 mg of CBD oil. These results indicate that CBD affects the release of cortisol and may act as a sedative. A recent analysis of CBD recruited 103 participants who suffered from anxiety and sleep deprivation. Researchers have studied the effects of CBD in combination with the effects of other prescription drugs. Classic CBD gummies like those present at the Shop CBD Oil Gummies for Sleep from JustCBD or Shop CBD Oil Gummies for Sleep from Olio Lusso. For muscle stiffness, Buy CBD Muscle Gel from Loxa Beauty
Side effects and other risks associated with CBD
The available evidence suggests that CBD is well tolerated. Some people report fatigue and psychological sedation with the CBD, but researchers believe it may be dose-related.
Taking 10-400 mg of CBD per day over a long period of time by various routes had no toxic effects on participants in a large retrospective study. Other researchers report that even doses of up to 1,500 mg per day are well tolerated. However, there’s more research necessary to prove if there is a long-term risk of using CBD. Up till now, there have been no reports of fatal CBD overdose. Some researchers may be concerned about probable CBD abuse, but information on serious complications is limited. One study suggests that considering 400-700 mg of CBD as a high dose may exacerbate cognitive impairment in people with schizophrenia. However, the combination of CBD and THC can improve cognition researchers report that CBD may have other adverse effects, including:
- Changes in cell viability in studies performed in cell cultures
- Decreased activity of P-glycoprotein and other drug transporters
- Decreased capacity of fertilization
- Drug metabolism inhibition in the liver
If confirmed, these effects on drug metabolism and transport indicate that CBD interferes with other drugs. Overall, more research is needed. Still, it’s a good idea for anyone considering using CBD to talk to their healthcare provider first.